FROM DEVELOPMENT
TO
Bioavailability
MANUFACTURING
We design your micronization with spray drying and test by permeation studies for high bioavailability.
We offer a wide range of innovation services, from development to industrialization and spray drying commercial production.
Fast Delivery
Just tell us more about your needs we will take care of everything.
Deep Expertise
Over 20 years of experience in innovation and technology transfer.
Keep it Simple
Just one partner to formulate, validate the efficacy and manufacture your products.
In Vivo studies
In Vivo studies
Formulation:
Complexes synthesis
Oral delivery systems
Transmucosal delivery systems
Development
Micronizzation
Efficacy validation:
Microbial activity (MIC)
Enzyme activity
Permeation studies
In Vivo studies
Industrializzation
permeation studies
spray dryer
Scale-up
Pilot production
Shelf-life (ICH)
Production
In Vivo studies
spray drying
Complexes
Micronization of extracts
Micro delivery systems
Spray Drying
Manufacturing conditions
Spray drying allows a one-step micronization and encapsulation of botanicals and phytocomplexes within a vehicle increasing either the absorption and the efficacy of the supplements and nutraceuticals.
Spray drying manufactured microparticles possess technological features solving the problems often related to traditionally formulated supplements, as poor absorption and bioavailability.
Manufacturing conditions
CONTRACT SPRAY DRYING SERVICES
We offer spray drying solutions from early-phase development to commercial products: clinical supply, scale-up, small commercial volumes of finished dose forms.
Fast to Market
Move quickly from your idea to commercial-scale manufacturing.
Deep Expertise
Over 20 years of experience in solid dosage forms, delivery technologies and spray drying.
Keep it Simple
Academic know how integrated with industry project management standards.
Water evaporation rate (kg/hr)
Solid percentage
Atomization
Feed tank
Manufacturing conditions
Manufacturing standard
Finished product testing
Micronization size
Controlled release
Active molecules protection
Packaging
up to 7
up to 50%
Rotary disc
30 lt heated
Cleanroom ISO 7
GMP
Shelf life ICH
5-30 µm
Possible
Possible
Bags/Drums
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“The health benefits of a nutraceutical will only be realized if it is actually absorbed by our bodies and reaches its intended site of action, such as our bloodstream, livers, lungs or brains.”
J. McClements, Springer Nature Switzerland, Future Food, 2019
What happen to supplement with no delivery strategy
Poor absorption and low bioavailability are only some of the problems affecting traditionally formulated supplements with no delivery strategy. After swallowing, a supplement is often weakened by the attack of the lytic enzymes and the acidic pH of the stomach.
The surviving dose is transported to the enteric tract. Here the absorption varies considerably depending on:
- speed of release from the formulation;
- of solubility in H2O;
- and for the lipophilic substances, on the emulsifying properties of the dosage form or on the presence of bile fluids.
The administration of herbal extracts without a strategy optimizing the bioavailability often results in products with little therapeutic impact, leaving the patient’s medical needs unfulfilled.
HOW SPRAY DRYING IMPROVES YOUR PRODUCTS
Micronization size between 5-30 µm
Controlled release
Active molecules protection
Botanicals, phytocomplexes, extracts and supplements all benefit from Spray drying micronization. This processes disperse them into several nano-compartments embodied within a monolithic matrix. This protects the medicinal substances from degradation, and allows to program the its release rate, improving bioavailability and efficacy.
The spray drying micronization allows the design of microdelivery systems protecting botanicals and phytocomplexes from the attack of the lytic enzymes and the acidic pH of the stomach. The dosage is preserved from off-target delivery.
The microdelivery system starts the liberation of the whole dosage only at a planned pH, increasing the on-target delivery, the absorption and bioavailability of the medicinal substance, and featuring:
- controlled speed of release of botanical or phytocomplex;
- High solubility also for lipophilic substances.
A supplement or botanicals when orally administrated is dissipated in an uncontrolled way already in the gastric environment (pH <2, Pure Compound) while, when conveyed within a microdelivery system is effectively concentrated at the absorption site, the enteric mucosa (pH> 6.5, Micro Delivery System).
Efficacy validation
studies:
in vitro, ex vivo, in vivo.
Understanding how a supplement works is the first step to improve its biological activity, to address a dosage form technological performance, to overcome market challenges and bring more value to the people using them.
CONTRACT SUPPLEMENT ANALYSIS
We offer a wide range of laboratory analysis for supplements, extracts, botanicals and phytocomplexes as permeation studies, and also dissolution, enzymatic activity, in vivo studies.
Fast Delivery
Just send us your samples we will take care of everything.
Deep Expertise
Over 20 years of experience in dosage forms analyses.
Keep it Simple
Just one partner to formulate, produce and validate the efficacy of your products.
Enzyme activity assay
Spectrophotometric methods
Spectrophotometric methods
Fluorescence methods
Chromatographic methods
HPLC
Permeation studies
Franz Cell (Pharmacopeia)
Franz Cell (Pharmacopeia)
Vertical cell model
Horizontal cell model
Validation (ICH guidelines)
Animal studies
Several amodels
Several models
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Permeation studies
A reliable tool for the efficacy validation of: solid, semisolid and liquid formulations.
The efficacy evaluation of formulation containing vitamins, botanicals and phytocomplexes benefits from the Franz Cell permeation model, designed to imitate the behaviour of dosage forms when in contact with the absorbing tissue. In the horizontal Franz cells, a membrane separates the donor from the receptor chamber housing a receptor solution and a stirrer. The system is kept at controlled temperature and steady stirring speed.
The test sample is placed in the donor chamber and in contact with the membrane allowing its eventual permeation into the receiving chamber. The permeation is measured collecting the receptor solution through the sampling port.
100 µl aliquots are collected by the sampling port at defined time intervals and analysed by spectroscopic detection, and the increasing accumulation of the diffused compounds are plotted against time.
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In vitro tests and cell culture models cannot accurately mimic the complexity of a living animal, to provide a comprehensive insight the supplement or botanical needs a real life conditions test.
In vivo studies
Animal studies incorporate supplements or botanicals into the diet of the animal model, to unravel the biological fate of the nutraceutical, such as absorption, metabolization, distribution, and excretion, as well as its physiological effects such as changes in blood pressure, glucose levels, cholesterol levels, physical activity up to tumour suppression.
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More services supporting the nutraceutical innovation.
Analytic & Characterization capacity
Our formulation development is powered by a significant scientific competence and an outstanding technological capacity.
- Zetasizer nano ZSP 2 MALVERN
- HPLC agilent 1200 series AGILENT
- Nano spray dryer B-90 BÜCHI
- HPLC-SEC agilent 1200 series AGILENT
- Microwave reactor discover CEM
- Mini spray drier B-290 BUCHI
- Rheometer DHR2 TA INSTRUMENTS
- Homogenizator at high pressure MICROFLUIDICS
