We design your micronization with spray drying and test by permeation studies for high bioavailability.

We offer a wide range of innovation services, from development to industrialization and spray drying commercial production. 

Fast Delivery

Just tell us more about your needs we will take care of everything.

Deep Expertise 

Over 20 years of experience in innovation and technology transfer.

Keep it Simple 

Just one partner to formulate, validate the efficacy and manufacture your products. 

In Vivo studies

In Vivo studies


Complexes synthesis

Oral delivery systems

Transmucosal delivery systems



Efficacy validation:

Microbial activity (MIC)

Enzyme activity

Permeation studies

In Vivo studies


permeation studies

spray dryer 


Pilot production

Shelf-life (ICH)


In Vivo studies

spray drying


Micronization of extracts

Micro delivery systems 

Spray Drying

Manufacturing conditions

Spray drying allows a one-step micronization and encapsulation of botanicals and phytocomplexes within a vehicle increasing either the absorption and the efficacy of the supplements and nutraceuticals.

spray drying integratori alta biodisponibilità
microparticle manufactured with spray dryer

Spray drying manufactured microparticles possess technological features solving the problems often related to traditionally formulated supplements, as poor absorption and bioavailability.

Manufacturing conditions


We offer spray drying solutions from early-phase development to commercial products: clinical supply, scale-up, small commercial volumes of finished dose forms. 

Fast to Market 

Move quickly from your idea to commercial-scale manufacturing.

Deep Expertise 

Over 20 years of experience in solid dosage forms, delivery technologies and spray drying.

Keep it Simple 

Academic know how integrated with industry project management standards.

Water evaporation rate (kg/hr)

Solid percentage


Feed tank

Manufacturing conditions

Manufacturing standard

Finished product testing

Micronization size 

Controlled release

Active molecules protection


up to 7

up to 50%

Rotary disc

30 lt heated

Cleanroom ISO 7


Shelf life ICH

5-30 µm




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“The health benefits of a nutraceutical will only be realized if it is actually absorbed  by our bodies  and reaches its intended  site of action, such as our  bloodstream, livers, lungs or brains.”

J. McClements, Springer Nature Switzerland, Future Food, 2019

What happen to supplement with no delivery strategy

Poor absorption and low bioavailability are only some of the problems affecting traditionally formulated supplements with no delivery strategy. After swallowing, a supplement is often weakened by the attack of the lytic enzymes and the acidic pH of the stomach.

low absorption

The surviving dose is transported to the enteric tract. Here the absorption varies considerably depending on:

  • speed of release from the formulation;
  • of solubility in H2O;
  • and for the lipophilic substances, on the emulsifying properties of the dosage form or on the presence of bile fluids.

The administration of herbal extracts without a strategy optimizing the bioavailability often results in products with little therapeutic impact, leaving the patient’s medical needs unfulfilled.


supplements or nutraceuticals and botanicals micro size

Micronization size between 5-30 µm

Controlled release

Active molecules protection

microparticles supplements

Botanicals, phytocomplexes, extracts and supplements all benefit from Spray drying micronization. This processes disperse them into several nano-compartments embodied within a monolithic matrix. This protects the medicinal substances from degradation, and allows to program the its release rate, improving  bioavailability and efficacy.

The spray drying micronization allows the design of microdelivery systems protecting botanicals and phytocomplexes from the attack of the lytic enzymes and the acidic pH of the stomach. The dosage is preserved from off-target delivery.

bioavailability of a microparticles

The microdelivery system starts the liberation of the whole dosage only at a planned pH, increasing the on-target delivery, the absorption and bioavailability of the medicinal substance, and featuring:

  • controlled speed of release of botanical or phytocomplex;
  • High solubility also for lipophilic substances.
controlled release

A supplement or botanicals when orally administrated is dissipated in an uncontrolled way already in the gastric environment (pH <2, Pure Compound) while, when conveyed within a microdelivery system is effectively concentrated at the absorption site, the enteric mucosa (pH> 6.5, Micro Delivery System).

Efficacy validation
in vitro, ex vivo, in vivo.

Understanding how a supplement works is the first step to improve its biological activity, to address a dosage form technological performance, to overcome market challenges and bring more value to the people using them.


We offer a wide range of laboratory analysis for supplements, extracts, botanicals and phytocomplexes as permeation studies, and also dissolution, enzymatic activity, in vivo studies. 

Fast Delivery

Just send us your samples we will take care of everything.

Deep Expertise 

Over 20 years of experience in dosage forms analyses.

Keep it Simple 

Just one partner to formulate, produce and validate the efficacy of your products. 

Enzyme activity assay

Spectrophotometric methods

Spectrophotometric methods

Fluorescence methods

Chromatographic methods


Permeation studies 

Franz Cell (Pharmacopeia)

Franz Cell (Pharmacopeia)

Vertical cell model

Horizontal cell model

Validation (ICH guidelines)

Animal studies

Several amodels

Several models

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Permeation studies

A reliable tool for the efficacy validation of: solid, semisolid and liquid formulations.

The efficacy evaluation of formulation containing vitamins, botanicals and phytocomplexes benefits from the Franz Cell permeation model, designed to imitate the behaviour of dosage forms when in contact with the absorbing tissue. In the horizontal Franz cells, a membrane separates the donor from the receptor chamber housing a receptor solution and a stirrer. The system is kept at controlled temperature and steady stirring speed.

The test sample is placed in the donor chamber and in contact with the membrane allowing its eventual permeation into the receiving chamber. The permeation is measured collecting the receptor solution through the sampling port.

100 µl aliquots are collected by the sampling port at defined time intervals and analysed by spectroscopic detection, and the increasing accumulation of the diffused compounds are plotted against time.

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In vitro tests and cell culture models cannot accurately mimic the complexity of a living animal, to provide a comprehensive insight the supplement or botanical needs a real life conditions test.

In vivo studies

Animal studies incorporate supplements or botanicals into the diet of the animal model, to unravel the biological fate of the nutraceutical, such as absorption, metabolization, distribution, and excretion, as well as its physiological effects such as changes in blood pressure, glucose levels, cholesterol levels, physical activity up to tumour suppression.

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More services supporting the nutraceutical innovation.

Analytic & Characterization capacity

Our formulation development is powered by a significant scientific competence and an outstanding technological capacity.

  • Zetasizer nano ZSP 2 MALVERN
  • HPLC agilent 1200 series AGILENT
  • Nano spray dryer B-90 BÜCHI
  • HPLC-SEC agilent 1200 series AGILENT
  • Microwave reactor discover CEM
  • Mini spray drier B-290 BUCHI
  • Homogenizator at high pressure MICROFLUIDICS