An Overview of Basic Concepts
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In vitro permeation tests play a vital role to understand how a dosage form interacts with biological membranes, unravelling the fundamental principles underlying the eventual permeation promotion or barrier effect of a formulation. This article explores the basics of permeation tests, including key concepts, methodologies, and applications.
What are in vitro permeation studies
In vitro permeation tests estimate the degree a dosage form promotes or inhibits the permeation of its ingredients across physiological mucosae. The most used model for permeation studies are the Franz cells.
How in vitro permeation studies are done
Franz cells make use of membranes to replicate the behave of the active ingredients of a dosage form when exposed to live mucosae. The membranes can be artificial or derived by animal tissues. These latter provide the most reliable results.
How technical files benefits from in vitro permeation tests
Permeation tests are useful to predict what is the most promising formula promoting or preventing the absorption of its ingredients, but no only. These studies are also pivotal in the technical files to present at the Notified Bodies.
How in vitro permeation studies help your formulation
1. Allow to screen several formulas to select those with the most favorable permeation profile.
2. Increases the success rate of expansive in vivo tests and clinical trials.
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