It is not easy to recover delays and design flaws.
Exploring Permeation Studies:
types of membranes
and reach new customers with your products.
Learn More About Permeation Studies
We are experts of in vitro permeation tests according for medical devices according EU 745/2017, and supplements according ICH Q2 (R1) and OECD No. 428.
We design your micronization with spray drying and test by permeation studies for high bioavailability.
Permeation studies are essential to understand how dosage forms interact with biological membranes, and provide valuable insights on how the components of a formulation diffuse across or are blocked by membranes. In this article, we explore the membranes used in the permeation studies, with a particular focus on comparing ex vivo with artificial membranes, and within ex vivo membranes highlighting the differences between swine and human membranes, their characteristics, applications, and implications in permeation studies.
Ex Vivo Membranes Vs Artificial
Ex vivo membranes are derived from living tissues and when properly stored retain their native structure, thickness and permeation. Ex vivo membranes bridge the gap between in vitro and in vivo studies, providing conditions closely resembling physiological systems, and thus valuable in application as drug efficacy and toxicology synthetic membranes are designed to mimic the properties and behavior of natural membranes, through specific engineered features as pore size, surface charge, and permeability.Â
Swine Vs Human Membranes
Swine membranes when employed in permeation studies are widely accepted as the surrogate of choose of human tissues. What makes them so widely accepted is their similarity with the human membranes such as structures, thickness and permeability. They offer a cost-effective and accessible alternative providing valuable data before advancing to human clinical trials.
Human Membranes are the most relevant models for permeation studies allowing for a direct correlation between formulation composition, active compound dose and effect.
Considerations
Permeation studies have broad applications ranging from evaluation of drug permeation, to formulation optimization. While ex vivo membranes provide a close representation of in vivo conditions, their availability, cost and limited lifespan can be a challenge. Artificial membranes offer greater control and reproducibility, but they may lack certain biological complexities. Swine membranes serve as valuable substitutes for human membranes, but species-specific differences need to be considered when extrapolating results to humans.
Conclusion
The permeation studies provide data over the eventual permeation or lack of the active compounds of the tested dosage form. These provide valuable insight on the quality of the dosage form formulation whether this shows an absorption promotion or barrier effect of its ingredients. Closer the study protocol is to the real life physiological conditions higher is the data reliability. Thus, the reliability grows when moving from artificial membranes to ex vivo, and within ex vivo from swine to human.
We are specialized in tailored spray drying for supplements and nutraceuticals. With our state-of-the-art know how we will help you to transform your classic products into highly bioavailable micronized supplements.
Technology Scientific is the SME born as an
 academic spin-off
our in vitro
permeation studies are used by
top companies and startups
Permeation study Packages Pricing
Every study includes
- Bibliographic research experimental protocol.
- Design, according to OECD guidelines.
- Franz cell selection, cell geometry.
- Selection of membranes, artificial or ex vivo.
- Test execution and permeation evaluation.
- Drafting of the report and delivery.
Development
1 analyte in 1 formulation
€ 3500
Updates: in real time
Email support: unlimited
Validation
Mobile assistence
Express delivery
VIDEO ANALYSIS OF THE REPORT
Most requested
Evaluation
3 analytes in 1 formulations
€ 7750
Updates: in real time
Email support: unlimited
Validation: according ICH
Mobile consultancy: 30 minutes
VIDEO ANALYSIS OF THE REPORT
Express delivery
Most requested
Line
6 analytes in 2 formulations
€ 11650
Updates: in real time
Email support: unlimited
Validation: according ICH
Mobile consultancy: 30 minutes
VIDEO ANALYSIS OF THE REPORT
Express delivery
Most requested
Express
7
Working
Days
€ 8199
Updates: in real time
Email support: unlimited
Validation: according ICH
Mobile consultancy: 30 minutes
VIDEO ANALYSIS OF THE REPORT
Express delivery
Most requested
Take the quiz below and find out now what is the best permeation package for you
What is your primary goal for this permeation study?
If you are developing a new formula and want to test the efficacy of the portotypes, or
if you want to increase customer product confidence with scienbtific data,
you can save time and money with a standrd protocol.
Formulating a new product
Optimizing the formula based on permeation studies.
Writing a technical file
Proving the permeation promotion or barrier effect for product authorization.
Building the product trust
Communicating the product's efficacy with laboratory data.
How many analytes do you need to test?
If you have a tentative number of analytes to test, move the sliders to the corresponding range.
If you know the exact number of analytes, overlap both sliders to the corresponding number.
How many formulations do you need to test?
If you have a tentative number of formulations to test, move the sliders to the corresponding range.
If you know the exact number of formulations, overlap both sliders to the corresponding number.
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With Technology Scientific in vitro permeation studies,
