An Overview of Basic Concepts
We are specialized in spray drying micronization of supplements and nutraceuticals for higher bioavailability. We are experts in preclinical studies as permeation studies according ICH and OECD guidelines.
We design your micronization with spray drying and test by permeation studies for high bioavailability.
Spray drying is a widely utilized technique for the production of powdered supplements made of thousands of amorphous micronized particles. The process offers several advantages raging from preservation of the nutritional value of the most heat sensitive compounds, improvement of the product stability, increase of storage time and transport flexibility. This article provides an overview of the basic concepts, key considerations, and benefits when this technique is applied for supplements.
The Spray Drying Process
Spray drying is a micronization process in which a liquid formulation, generally called the feed, is transformed into a dry powder through a thermodynamic process schematically divided in 3 phases:
3. Particle formation
The feed is atomized into fine droplets by a nozzle, increasing the surface area of the liquid and increasing the drying speed. The nozzle can be of several types: pressure, rotary, or two-fluid.
The atomized droplets are formed within the drying chamber, in which a hot-drying gas stream exchange heat with the droplets using it either to increase their temperature and to induce a quick evaporation of the liquid component.
As the liquid evaporates from the droplets the solid component starts to interact and to form the solid particles. The characteristics of the final product such as size, morphology, and density, is influenced by processes parameters as feed composition, dry gas inlet temperature and flow rate.
Key Considerations in Spray Drying:
Key factors for a successful spray drying micronization:
1. Particle Size and Morphology
2. Feed Formulation
3. Temperature and flow rate of the drying gas
When preparing the feed it has to be considered how it will behave during the drying processes avoiding aggregation, high viscosity, and heat sensible components. If one these is overlooked the efficiency of the drying processes is compromised.
The efficiency of the drying processes is directly linked to the final production costs and quality consistency across the butches.
Particle Size and Morphology
Particle size and morphology influence the microparticle rate surface-area/volume, bulk density and porosity, which are linked to powder flowability and dispersibility, important for the further processing as mixing, compression or encapsulation. While microparticle surface-area/volume rate is an important parameter to regulate the active compound liberation, which is linked to solubility and bioavailability.
Spray drying is a valuable technique in the production of powdered supplements and the comprehension of its basic concepts unsure a successful transformation of classic products into highly effective supplements actually improving their well-being. A masterfully optimized micronization process also allow supplement companies to produce at lower costs and market higher added value products.
Why micronize with us
Fast To Marketvv
Fast To Market
Move quickly from your idea to prototype, scale-up and commercial-scale manufacturing.
Over 20 years of experience in solid dosage forms, delivery technologies and spray drying.
Keep It Simpl
Keep It Simple
State of the art know how integrated with industry project management standards.
Ready to tell us more about your project?
Use the chat button below to talk with us or send us an
We are specialized in tailored spray drying for supplements and nutraceuticals. With our state-of-the-art know how we will help you to transform your classic products into highly bioavailable micronized supplements.